Endoglin (CD105) Up-regulation in Pulmonary Microvasculature of Ventilated Preterm Infants

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Endoglin (CD105) up-regulation in pulmonary microvasculature of ventilated preterm infants.

RATIONALE Preterm infants exposed to mechanical ventilation and oxygen are at risk for bronchopulmonary dysplasia (BPD), a multifactorial chronic lung disorder characterized by arrested alveolar development. Studies have described disruption of microvascular development in BPD, characterized by primitive angioarchitectural patterns reminiscent of the canalicular/saccular stages of lung developm...

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RATIONALE Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE To perform a comprehensive analysis of the early and late effects of ventilation on pulmonary microvascular growth in preterm infan...

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ژورنال

عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine

سال: 2008

ISSN: 1073-449X,1535-4970

DOI: 10.1164/rccm.200608-1240oc